Note:

This calculator determines the minimum number of samples required to ensure a specified level of accuracy and confidence in measurement results. It is especially useful for laboratory quality control, clinical diagnostics, and statistical sampling.

Understanding Parameters:

• Z-Score (Z): Represents the confidence level. For example, 1.96 corresponds to a 95% confidence level, and 2.58 corresponds to a 99% confidence level.
• Analytical Coefficient of Variation (CVA): Reflects the precision of the measurement method in percentage terms.
• Within-Subject Biological Variation (CVI): Represents the natural variability within an individual over time, expressed as a percentage.
• Acceptable Deviation (D): Defines the allowable percentage difference from the true value for the measurement.

Applications:

• Clinical Diagnostics: Ensures accurate patient results by accounting for biological and analytical variability.
• Laboratory Quality Control: Determines the sample size required to maintain consistent testing accuracy.
• Statistical Sampling: Supports research and industrial processes by ensuring reliable measurements with specified confidence.